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Dexmedetomidine, Propofol and their combination for sedation of patients with alcohol drawal syndrome in the intensive care unit: prospective controlled study

The anesthesiologist and specialist on medical emergency conditions

Objective – to evaluate the efficacy and safety of dexmedetomidine, propofol, and their combination for sedation of patients with alcohol drawal syndrome in the intensive care unit.

Materials and Methods. The study included 210 patients, which were assigned in four groups – group of dexmedetomidine, propofol, dexmedetomidine and propofol and control group. Duration of stay in the intensive care unit was 51 h [46–75], 68 h [48– 98], 68 h [48–78] and 92 h [70–102].

Results. Diazepam consumption and the number of patients, who required haloperidol, were less and sedation quality and patients communication were better in study groups compared with the control group.

Conclusion. Dexmedetomidine, propofol, and their combination are effective and safe for patients with alcohol drawal syndrome in the intensive care unit.

Key words: alcohol with drawal state, sedation, propofol, dexmedetomidine, diazepam.

Authors: Bielka K., Glumcher F., Kuchyn I., Muhumorov A., Perebiynis M. (O.O.Bogomolets National Medical University, Kyiv).

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