Эффективность терапии пациентов с ишемической болезнью сердца с использованием фиксированной комбинации L-аргинина и L-карнитина с точки зрения доказательной медицины (обзор международных научных источников)

Эндокринолог, Кардиолог, Невропатолог, Терапевт

Цель: анализ источников научной литературы по применению аминокислот L-аргинина и L-карнитина при ишемической болезни сердца.

Объект и методы исследования. Проведен поиск литературных источников в основных электронных базах данных доказательной медицины: BMJ Clinical Evidence, Medscape from WebMD, Centers for Disease Control and Prevention, The Cochrane Collaboration The Cochrane Library, The National Center for Biotechnology Information, Health-ua.com стратегии поиска: «L-карнитин», «карнитин», «L-аргинин», «Тиворель», «ишемическая болезнь сердца». Электронный поиск дополнен ручным поиском. Результаты. Полученные научные источники разделены на три группы: исследования по эффективности только L-аргинина, только L-карнитина и одновременно обоих. Данные многочисленных зарубежных и отечественных исследований свидетельствуют о длительном позывном эффекте отдельного применения L-аргинина и L-карнитина в терапии пациентов с ишемической болезнью сердца. Следующим этапом исследования был поиск научных публикаций по применению препарата, в состав которого входят обе аминокислоты (Тиворель, «Юрия-Фарм», Украина) в базах источников доказательной медицины. Представлены данные 4 рандомизированных исследований L-аргинина и L-карнитина, проведенных за последние 10 лет в Украине.

Ключевые слова: ишемическая болезнь сердца, L-аргинин, L-карнитин

Выводы:

Результаты проведенного анализа данных литературы позволяют назначать лекарственные средства, в состав которых входят аминокислоты L-аргинин и L-карнитин как кардио- и ендотелиопротекторни препараты, и рекомендовать применять их комбинации для лечения пациентов с ишемической болезнью сердца. Перспективными являются дальнейшие исследования эффектов этих аминокислот и разработка клинических рекомендаций по их рациональному применению в кардиологии.

Авторы:

Шумаков В.А., д.мед.н., Национальный научный центр «Институт кардиологии имени академика Н.Д. Стражеско» АМН Украины, Киев

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30 июля, 2021