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Neurosurgeon, The anesthesiologist and specialist on medical emergency conditions, Neurologist

How is edaravone effective against acute ischemic stroke and amyotrophic lateral sclerosis?

Abstract. Edaravone is a low-molecular-weight antioxidant drug targeting peroxyl radicals among many types of reactive oxygen species. Because of its amphiphilicity, it scavenges both lipid- and water-soluble peroxyl radicals by donating an electron to the radical. Thus, it inhibits the oxidation of lipids by scavenging chain- initiating water-soluble peroxyl radicals and chain-carrying ...