From 15 to 16 million people suffer a stroke every year, of which 100-110 thousand are residents of Ukraine. This vascular desiase ranks first among causes of disability and is one of the leading causes of death. One third of patients die during the first year after stroke, one out ...
Abstract. Background. In acute ischemic stroke (AIS), more than 1,000 substances with known neuroprotective effects have been studied, but their effectiveness is considered insufficiently convincing. In 2018, Ukraine launched the release of a new free radical scavenger Xavron (active ingredient — edaravone), which since 2001 has been successfully prescribed in ...
Edaravone, a novel free radical scavenger, demonstrates neuroprotective effects by inhibiting vascular endothelial cell injury and ameliorating neuronal damage in ischemic brain models. The present study was undertaken to verify its therapeutic efficacy following acute ischemic stroke. We performed a multicenter, randomized, placebo-controlled, double-blind study on acute ischemic stroke patients ...
L-arginine is a conditionally essential amino acid that was first isolated in 1886 by E. Schulze and E. Steiger, and its structure was established by E. Schulze and E. Winterstei in 1897 [1]. L-arginine is used several times ways for the synthesis of protein and low molecular weight bioactive substances ...
Materials of the XXI International Scientific and Practical Conference “Interdisciplinary Issues in Modern Neurology”, April 22-24, Truskavets, Ukraine. Considerable attention was paid to the problematic aspects of management of patients with acute ischemic stroke. Within the framework of separate scientific symposium was held a discussion about the possibilities of modern ...
Background: A free radical scavenger, edaravone, which has been used for the treatment of ischemic stroke, was reported to cause acute kidney injury (AKI) as a fatal adverse event. The aim of the present study was to clarify whether edaravone is associated with AKI in patients with acute ischemic stroke. ...
The literature review considers the prospect of resuming active use of sugar alcohols in the practice of intensive care. The information is focused on the characteristics of the metabolism and the expected effects of sugar five-carbon alcohol xylitol. The feasibility of using xylitol solutions is justified by reducing the risk ...
Postoperative ileus (POI) occurs after many surgical interventions, but most often after abdominal operations — with a frequency of 10–30 %. This complication increases postoperative morbidity, duration of hospitalization and cost of treatment. In the Cochrane systematic review, it was shown that none of the routinely used prokinetic drugs (neostigmine, ...
The scientific-practical conference “Opportunities and Achievements of Modern Pharmacotherapy in the Practice of a Neurologist” held in Kharkov on March 14-15, 2019. It was organized by Association of Neurologists, Psychiatrists and Narcologists of Ukraine, Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine, Kharkiv ...
Effect of Edaravone on Favorable Outcome in Patients with Acute Cerebral Large Vessel Occlusion: Subanalysis of RESCUE-Japan Registry (Neurol. Med. Chir. (Tokyo), 2015 March; 55(3)) Edaravone with and without .6 Mg/Kg Alteplase within 4.5 Hours after Ischemic Stroke: A Prospective Cohort Study (PROTECT4.5) (Journal of Stroke and Cerebrovascular Diseases, 2017, ...Load more