Application of “Refex” at patients with purulent infections of pararectal areas

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Application of “Refex” at patients with purulent infections of pararectal areas

Summary. The influence of an antibacterial drug “Refex” for treatment of patients with extensive purulent infections of pararectal areas are evaluated in the article.

Efficiency “Refex” at 40 patients is analysed.

Results of research testify a high antibacterial efficiency of the drug that testifies “Refex” as a treatment of choice in patients with extensive purulent infections in pararectal areas.

Key words: “Refex”, colorectal surgery, purulent infections.

Authors: Kucher М.D., Yaremchuk I.J., Dubovoy V.A.

Literature:

  1. Ривкин В.Л., Бронштейн А.С., Фаин С.Н. Руководство по колопроктологии: Монография. – М.: Медпрактика, 2001. – 300 с.
  2. Мальцев В.Н. Медицинская реабилирация больных с неопухолевыми заболеваниями прямой кишки, анального канала и мягких тканей промежности: Монография. – Харьков: Торнадо, 2004. – 202 с.
  3. Craig W.A. Basic pharmacodynamics of antibacterials with clinical applications to the use of beta-lactams, glycopeptides, and linezolid. Dis.Clin. North Am. 2003; 17:479–501.
  4. Drusano G.L. Antimicrobial pharmacodynamics: critical interactions of ‘bug and drug’. Rev.Microbiol. 2004; 2:289–300.
  5. Березняков І.Г. Стан антибіотикорезистентності в Україні: результати дослідження АУРА. Здоров’я України ХХІ вік. 2020; тематичний номер (4): 31-34.; тематичний номер (5): 21-23.
  6. Yang H., Cui X., Ma Z., et al. Clinical outcomes with alternative dosing strategies for piperacillin/tazobactam: a systematic review and meta-analysis. PLoS One. 2015; 19 (2): 274–89.
  7. Dohmen PM. Influence of skin flora and preventive measures on surgical site infection during cardiac surgery. Surg Infect. 2006; 7:S13–7.
  8. American Society of Health-System Pharmacists. ASHP therapeutic guidelines on antimicrobial prophylaxis in surgery. Am J Health-Syst Pharm. 1999; 56:1839–88.
  9. Березняков И.Г. Аллергические реакции на антибиотики. Харьков: ГО УАДВА, 2021. – 58 с.
  10. Erasmo AA, Crisostomo AC, Yan LN, eta al. Asian J Surg. 2004;27(3):227-235.
  11. list.essentialmeds.org/medicines/320, Національний перелік лікарських засобів України.
  12. Hauser AR, Sriram P. Severe Pseudomonas aeruginosa infections. Tackling the conundrum of drug resistance. Postgrad Med. 2005 Jan;117(1) :41-8. doi: 10.3810/pgm.2005.01.1571. PMID: 15672890.