REFEX is a combined antibacterial drug containing piperacillin, a semi-synthetic broad-spectrum antibiotic, and tazobactam, an inhibitor of most beta-lactamases. It has a wide range of action (Gr +, Gr-, anaerobes, protozoa), high clinical efficacy and low resistance in microorganisms.
Mechanism of action
Piperacillin – inhibits cell wall synthesis.
Tazobactam is an inhibitor of Richmoid Sykes’ beta-lactamase class IІІ: penicillinase and cephalosporinase.
The drug has bactericidal activity.
• severe pneumonia, including nosocomial and ventilator-associated pneumonia;
• complicated intra-abdominal infections;
• complicated infections of the skin and soft tissues, urinary system;
• bacterial infections in patients with neutropenia and fever with suspected bacterial infection
Powder for solution for infusion.
1 vial of the drug (4500 mg) contains:
• piperacillin 4000 mg,
• tazobactam 500 mg.
Mode of application: intravenously.
Age restrictions: Do not apply to children under 2 years.