REFEX is a combined antibacterial drug containing piperacillin, a semi-synthetic broad-spectrum antibiotic, and tazobactam, an inhibitor of most beta-lactamases. It has a wide range of action (Gr +, Gr-, anaerobes, protozoa), high clinical efficacy and low resistance in microorganisms.

Mechanism of action

Piperacillin – inhibits cell wall synthesis.
Tazobactam is an inhibitor of Richmoid Sykes’ beta-lactamase class IІІ: penicillinase and cephalosporinase.
The drug has bactericidal activity.


  • severe pneumonia, including nosocomial and ventilator-associated pneumonia;
  • complicated intra-abdominal infections;
  • complicated infections of the skin and soft tissues, urinary system;
  • septicemia;
  • bacterial infections in patients with neutropenia and fever with suspected bacterial infection

Dosage form:

Powder for solution for infusion.

1 vial of the drug (4500 mg) contains:

  • piperacillin 4000 mg,
  • tazobactam 500 mg.

Mode of applicationintravenously.

Age restrictionsDo not apply to children under 2 years.

How supplied
4500 mg
Sales markets