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REFEX is a combined antibacterial drug containing piperacillin, a semi-synthetic broad-spectrum antibiotic, and tazobactam, an inhibitor of most beta-lactamases. It has a wide range of action (Gr +, Gr-, anaerobes, protozoa), high clinical efficacy and low resistance in microorganisms.

Mechanism of action

Piperacillin – inhibits cell wall synthesis.
Tazobactam is an inhibitor of Richmoid Sykes’ beta-lactamase class IІІ: penicillinase and cephalosporinase.
The drug has bactericidal activity.


• severe pneumonia, including nosocomial and ventilator-associated pneumonia;
• complicated intra-abdominal infections;
• complicated infections of the skin and soft tissues, urinary system;
• septicemia;
• bacterial infections in patients with neutropenia and fever with suspected bacterial infection

Dosage form:

Powder for solution for infusion.

1 vial of the drug (4500 mg) contains:
• piperacillin 4000 mg,
• tazobactam 500 mg.

Mode of application: intravenously.

Age restrictions: Do not apply to children under 2 years.

How supplied

  • 4500 mg

Sales Markets


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