Clinical results of application of injectable implant of hyaluronic acid and sodium succinate in combustiology

Endocrinologist, Combustiology, Neurologist, Neurosurgeon, General practitioner, Surgeon

Kharkiv Medical Academy of Postgraduate Education, Department of Combustiology,
Reconstructive and Plastic Surgery

Literary source data analysis indicates a direct impact of Extra Cellular Matrix (ECM) condition on tissue regeneration processes in case of injuries and surgical interventions. In particular, enhancement of fibroblast proliferative activity is accompanied by increased production of glycosaminoglycans (GAGs) – namely, hyaluronic acid (HA) and sodium succinate. That is providing optimal conditions of neocollagenogenesis locally determines the increase of tissue need in HA with specific biological properties. R. Donoff regards the functional significance of a GAG:
—as collagen biosynthesis monitoring;
—direct participation in the organization of fibrous network;
—providing stabilization of collagen fibres.

Thus, wound healing and scar formation process is directly dependent on the ability of tissues to synthesize the sulphate-containing GAGs [1-19]. Modern medical technologies enable realizing the mechanism of direct HA injection in tissues with high needs.

Study objective:
assessment of efficacy and tolerability of injectable implant based on 1.5% hyaluronic acid and sodium succinate in pre-filled syringes manufactured by “Yuria-Pharm” LLC in burned patients with donor wounds after autodermoplasty with area of up to 5% of the body surface.

Study tasks:
—to study therapeutic efficacy of the study drug – injectable implant based on 1.5% hyaluronic acid and sodium succinate applicable in burned patients with donor wounds after autodermoplasty;
— to study tolerability and possible side effects/reactions in using the study drug;
— to compare treatment results received in the use of injectable implant based on 1.5% hyaluronic acid and sodium succinate and standard therapy to assess superior drug efficacy compared to standard therapy.

Injectable implant based on 1.5% hyaluronic acid and sodium succinate is a colourful, transparent, cohesive gel of non-stabilized hyaluronic acid of non-animal (bioenzymatic) origin, sterile, pyrogen-free, with a physiological pH. Hyaluronic acid is naturally occurring polysaccharide (glycosaminoglycan), an important structural element of skin and connective tissue. Sodium succinate provides powerful regenerative and antioxidant effect, enhances cellular and tissue respiration, ion transport, protein synthesis, as well as strong stimulation of energy production (ATP) and microcirculation enhancement.

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