Paracetamol, as a component of multimodal postoperative analgesia in severe orthopedic trauma care

Shupyk National Medical Academy of Postgraduate Education, Kiev
Ukrainian Scientific and Practical Center of Emergency Medical Care and Disaster Medicine, Kiev
Kiev City Clinical Emergency Care Hospital

Summary. The article is devoted to the optimization of multimodal postoperative analgesia in patients with severe orthopedic trauma. It has been proved that paracetamol, as a component of multimodal postoperative analgesia in patients with severe orthopedic trauma decreases the severity of pain syndrome and sedation effect, limits opioid analgesic consumption in postoperative period. Administration of the intravenous form of parace-tamol — Infulgan — provides the stabilization of mean arterial pressure, heart rate, total peripheral resistance, and peripheral temperature. The elevated levels of hepatic transaminases in post-traumatic period were associat-ed with severity of orthopedic trauma, but not with paracetamol prescription.

Key words: severe trauma, multimodal analgesia, adverse events, paracetamol.