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The effectiveness of intravenous administration of iron sucrose to parturient women with iron metabolism disorders after abdominal delivery

Obstetrician-gynecologist

Aim – to evaluate the effectiveness of treatment of iron metabolism disorders with iron sucrose in case of increased blood loss during cesarean section.

Materials and methods. The study included 156 women aged 22–38 years with an initial hemoglobin level of 92–105 g/l and intraoperative blood loss of 650–850 ml (≈0.6–0.8% of body weight). Of these, 62 women with hemoglobin in the 3rd trimester of pregnancy 88–99 g/l (Group I), 62 women with hemoglobin 100–105 g/l (Group II). All women in groups I and II were administered iron saccharate (Sufer, Yuriya-Pharm) in the early postoperative period, Group III consisted of 32 parturient women with hemoglobin 88–99 g/l, who were prescribed ferrous sulfate 200 mg Fe²⁺ daily for 14 days.

Results. According to fatigue assessment, women in all groups felt fatigue after abdominal delivery. In Group II, the fatigue index on day 2 was much lower than in Groups I and III. A rapid recovery of hemoglobin and ferritin was observed in Groups I and II 48 hours after drug administration, but the indicators of Group II reflected a faster rate of recovery of iron metabolism in contrast to the retention of increased fatigue in women in Group III, which lasted longer and was more pronounced.

Keywords: pregnancy, cesarean section, bleeding, anemia, iron deficiency.

Authors:

Davydova Yuliya Volodymyrivna – MD, prof., head of the department of obstetric problems of extragenital pathology of the State Central Medical Center of the National Academy of Medical Sciences of Ukraine, master of public administration.
Lymanska Alisa Yuriivna – PhD, senior researcher of the department of obstetric problems of extragenital pathology and ethical problems in medicine of the State Central Medical Center of the National Academy of Medical Sciences of Ukraine; associate professor of the National Medical University named after O.O. Bogomolets.
Kravets Olga Mykhailivna – obstetrician-gynecologist of the department of extragenital pathology of the State Central Medical Center of the National Academy of Medical Sciences of Ukraine.
Landyak Yuliya Vasylivna – junior researcher of the department of obstetric problems of extragenital pathology and ethical problems in medicine of the State Central Medical Center of the National Academy of Medical Sciences of Ukraine.

Conclusions:

Early use of intravenous iron sucrose in combination with anemia and moderate blood loss after cesarean section promotes accelerated recovery of hemoglobin and iron stores, reduces clinical manifestations of posthemorrhagic syndrome and reduces the frequency of blood transfusions.

The study was carried out in accordance with the principles of the Declaration of Helsinki. The informed consent of the children’s parents was obtained for the research.

No conflict of interests was declared by the authors.

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