The efficacy of Decasan antiseptic agent

Otolaryngologist, Pulmonologist, General practitioner, Surgeon, Obstetrician-gynecologist, The anesthesiologist and specialist on medical emergency conditions, Combustiology, Orthopaedic Trauma

Vinnitsa Pirogov Memorial National Medical University, Pirogova Str. 56, Vinnitsa, Ukraine 21018;
Yuria-Pharm Pharmaceutical Company, Amosova Str.10 Kyiv, Ukraine 01000


Abstract. The work presents the results of study of antimicrobial properties of batch production samples of antiseptic pharmaceutical products Decasan and Myramistin. Experience of clinical use of Decasan in treatment of patients with purulent and inflammatory lesions was summarised.

Key words: antiseptic agents, Decasan, therapeutic efficacy, pneumonia. 

Introduction
The aetiological structure of purulent inflammatory disease is dominated by opportunistic organisms, which are characterised by multiple resistance to antibiotics. The horizontal conjugative transmission of genetic determinants of resistance within the microbial population promotes propagation of antibiotic resistance, which develops substantially faster than marketing of new and effective drugs. Along with peculiarities of pharmacokinetics of systemic drugs, which does not allow creating required concentrations of a focus of infection, separated by a wall of inflammation, the above mentioned factor makes local antiseptic agents increasingly important within the therapeutic schedules for local purulent and inflammatory disease.

Compared to the number of antibiotics, the list of contemporary antiseptic agents is quite scarce, containing such agents, known for already a long time, as hydrogen peroxide, nitrofuran compounds, chlorhexidine bigluconate and povidon-iodine. In recent years, the above list was substantially complemented by the products of quaternary ammonium compounds, synthesised in Ukraine, namely, myramistin and decamethoxin.

Surface active cationic detergents, which include decamethoxin and myramistin, are known for a wide range of bactericidal, virucidal, fungicidal action, their ability to reduce adhesive properties of bacteria and to destroy microbial toxins [Paliy, 1997]. Local application of the above agents allows creating the antiseptic regimen in the infective focus, required for fast wound healing and elimination of inflammation, as well as accelerating restoration of homeostasis.

Learn more

Cardiologist

The characteristics of preventive and therapeutic effectiveness of new domestic anti-septic medicinal product Horosten

The epidemiological situation at the end of the second millennium is characterized by a shift of etiological structure of infectious diseases towards those caused by opportunistic potentially pathogenic microorganisms.
Cardiologist

Decametoxin-based anti-septic solutions vs povidone-iodine in preventive therapy of the skin in venous catheter care

Venous catheters are the most common devices implanted to provide venous access for patients’ treatment.