The role of intravenous acetaminophen in treatment of acute pain: literature review and first-hand experience

Obstetrician-gynecologist, The anesthesiologist and specialist on medical emergency conditions, Combustiology, Neurologist, Orthopaedic Trauma, Surgeon

Dnepropetrovsk regional clinical hospital named after I.I. Mechnikov
Dnepropetrovsk State Medical Academy


Abstract. The paper is based on the literature review and first-hand experience and deals with the efficacy and safety of intravenous acetaminophen in treatment of acute pain syndromes, including a severe multitrauma.

Keywords: acetaminophen, intravenous, acute pain, multitrauma.

Literature review. Acetaminofen (paracetamol) was synthesized in 1878, investigated in a clinic in 1887 and has been widely used in medicine since 1950 [1]. Since then, it was recognized as a safe and efficient analgesic and antipyretic in children and adult patients [1-4]. Since 2001, acetaminophen became available in Europe for intravenous injection under the trade mark Perfalgan (Bristol-Myers Squibb). Since 2011, the use of intravenous form of acetaminophen (Infulgan, Yuria-Pharm) has become possible, which allowed to expand its application for treatment of pain syndromes of various etiology.

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