THE ROLE OF INTRAVENOUS ACETAMINOPHEN IN TREATMENT OF ACUTE PAIN: LITERATURE REVIEW AND FIRST-HAND EXPERIENCE

Dnepropetrovsk regional clinical hospital named after I.I. Mechnikov
Dnepropetrovsk State Medical Academy


Abstract. The paper is based on the literature review and first-hand experience and deals with the efficacy and safety of intravenous acetaminophen in treatment of acute pain syndromes, including a severe multitrauma.

Keywords: acetaminophen, intravenous, acute pain, multitrauma.

Literature review. Acetaminofen (paracetamol) was synthesized in 1878, investigated in a clinic in 1887 and has been widely used in medicine since 1950 [1]. Since then, it was recognized as a safe and efficient analgesic and antipyretic in children and adult patients [1-4]. Since 2001, acetaminophen became available in Europe for intravenous injection under the trade mark Perfalgan (Bristol-Myers Squibb). Since 2011, the use of intravenous form of acetaminophen (Infulgan, Yuria-Pharm) has become possible, which allowed to expand its application for treatment of pain syndromes of various etiology.