The role of intravenous acetaminophen in treatment of acute pain: literature review and first-hand experience

Combustiology, Neurologist, Obstetrician-gynecologist, Orthopaedic Trauma, Surgeon, The anesthesiologist and specialist on medical emergency conditions

Dnepropetrovsk regional clinical hospital named after I.I. Mechnikov
Dnepropetrovsk State Medical Academy


Abstract. The paper is based on the literature review and first-hand experience and deals with the efficacy and safety of intravenous acetaminophen in treatment of acute pain syndromes, including a severe multitrauma.

Keywords: acetaminophen, intravenous, acute pain, multitrauma.

Literature review. Acetaminofen (paracetamol) was synthesized in 1878, investigated in a clinic in 1887 and has been widely used in medicine since 1950 [1]. Since then, it was recognized as a safe and efficient analgesic and antipyretic in children and adult patients [1-4]. Since 2001, acetaminophen became available in Europe for intravenous injection under the trade mark Perfalgan (Bristol-Myers Squibb). Since 2011, the use of intravenous form of acetaminophen (Infulgan, Yuria-Pharm) has become possible, which allowed to expand its application for treatment of pain syndromes of various etiology.

Learn more

Cardiologist

The characteristics of preventive and therapeutic effectiveness of new domestic anti-septic medicinal product Horosten

The epidemiological situation at the end of the second millennium is characterized by a shift of etiological structure of infectious diseases towards those caused by opportunistic potentially pathogenic microorganisms.
Cardiologist

Decametoxin-based anti-septic solutions vs povidone-iodine in preventive therapy of the skin in venous catheter care

Venous catheters are the most common devices implanted to provide venous access for patients’ treatment.
Combustiology

Paracetamol, as a component of multimodal postoperative analgesia in severe orthopedic trauma care

Today postoperative analgesia performed in the intensive care units is aimed, primarily, at prevention and management of pain syndrome in patients.
Combustiology

Efficacy and safety of intravenous parace-tamol in the early postoperative period after minor surgical interventions

The problem of pain remains one of the global and un-resolved issues in modern medicine.