Bogomolets National Medical University,Kiev

Experiental study on 32 animals allowed to demonstrate and evaluate the severity of the antioxidant effect of a combination of hyaluronate and succinate compared with monotherapies hyaluronate. Clinical efficacy of a combination of hyaluronate and succinate in the product Diart in the treatment of patients with osteoarthritis of the knee joint was detected in 126 patients. Was found significant improvement in treatment results in the aspect of security, stability and the resulting prolongation of clinical benefit.

Key words: osteoarthritis, hyaluronate, succinate, treatment.

The issue of searching new methods and pharmacological products for treatment of patients with osteoarthritis is important today due to the fact that the disease embraces almost 80% in the total joint pathology in individuals older than 60 years, 10-30% of cases of osteoarthritis leads to varying degrees of disability. Despite significant advances in the diagnostics and treatment of osteoarthritis, many aspects of its pathogenesis are not fully explored, for which reason medication is often limited to symptomatic pharmacological agents that are not able to provide a stable remission. It was reported that in the last 30-40 years an osteoarthritis incidence increased by 5-9 times. Demographic parameters in Europe and USA confirm continuing “aging” of the population and increase in proportion of people over 60 years. According to preliminary estimates, the population of this age group will double in 2020 [5].