The Ministry of Healthcare of Ukraine
The O.O. Bogomolets National Medical University
The Department of Trauma and Orthopedics
The methods of study – morphologic and histological examination; biochemical assays; studies of the antioxidant protection system (spontaneous and induced chemiluminescence as an index of free-radical peroxidation intensity), the methods of statistical analysis.
The experiments involved 32 adult rabbits, weighting 2.9 ± 0.15 kg, employing the model of the transcartilage lesion of the articular cartilage in the knee joint. Hyaluronic acid/sodium succinate combination («Hyalual®-ARTRO» preparation) and the monopreparation of hyaluronic acid, both agents administered intraarticularly, were compared concerning their influence upon development (preventive action) and progression (therapeutic action) of osteoarthrosis of the knee joint and the reparative chondrogenesis in the articular cartilage. Also, the activities of the free-radical lipid peroxidation system (FRLP) in plasma and homogenates of hepatic and myocardial tissues were assessed, as well as alterations of the biochemical markers of cartilaginous and osseous metabolism, as detected in blood serum in articular injuries.