Umerox Inhal

Umerox^® Inhal is an individual device designed for inhalation use of methoxyflurane.

Low-dose methoxyflurane provide analgesia.

According to the ATС classification, methoxyflurane is an analgesic (N02BG09).

Dossage form:

• vapors for inhalation, liquid, 3 ml

Active Ingredient:

• methoxyflurane 99,9%

Umerox^® Inhal includes:

• liquid (methoxyflurane) 3 ml in polymer cartridges
• individual device for inhalation Umerox^® Inhal
• procedure set for Umerox^® Inhal (nasal clip and mouthpiece)

Indications for the use of Umerox^® Inhal:

• Emergency pain relief in hemodynamically stable patients with trauma and associated pain who are conscious, by self-administration under the supervision of personnel who has been trained in the use of this medicinal product.
• Pain relief in conscious patients who are under observation and require analgesia during surgical procedures such as dressing changes.

Umerox^® Inhal provides:

• rapid onset of analgesic effect (1);
• moderate anti-anxiety effect (2);
• painless, atraumatic administration – no injections;
• the patient is conscious and controls the degree of analgesia (3);
• non-opioid (1).

In accordance with the Order of the Ministry of Health of Ukraine No. 1122 dated June 28, 2022. Methoxyflurane is included in the “Methodical recommendations for analgesia of victims during evacuation stages”. Methodological recommendations regulate the provision of assistance by emergency medical aid teams at the pre-hospital stage and at the early hospital stage in health care institutions.

Methoxyflurane is included in the 17th issue of the State Formulary – Order of the Ministry of Health of Ukraine dated 06/13/2025 No. 971. According to the provisions on the “State Formulary”, this is one of the industry health standards that contains a list of medicines registered in Ukraine, which includes high-quality, effective, safe, economically feasible medicines, as proven by evidence-based medicine and medical practice.

Umerox^® Inhal is intended for independent use under supervision, or if necessary, with the help of a specialist who has the appropriate experience and medical education, and also knows the technique of using this device.

After completing the first dosage from the Umerox^® Inhal kit, you can use a second (replaceable) cartridge until the maximum daily dose of 6 ml is reached.

Replacement cartridge – Umerox^® Inhal, vapor for inhalation, 3 ml liquid in a polymer cartridge.

Method of use

Step 1.

Install the mouthpiece on the outlet of the device, install the clip on the patient’s nose so that it is impossible to breathe through the nose.

Step 2.

Press the button on the top with your thumb until it stops in order to introduce the liquid for inhalation into the device.

Step 3.

Before using the device, make light oscillatory (circular) movements for better distribution and evaporation of the drug Umerox^® Inhal.

The device is ready for use.

The patient should start inhaling the drug Umerox^® Inhal 5 minutes before the start of the manipulation and continue throughout it.

The patient should take the first 2–3 breaths shallowly, after which he should inhale as usual. Exhalations should be made only through the mouthpiece inside the device, since the remnants of the substance after exhalation are retained by the sorbent in the deactivation chamber in the device body.

The patient should be instructed to inhale intermittently and may stop breathing through the device on their own after adequate analgesia has been achieved. When pain returns, the patient can resume breathing through the device on their own. Continuous administration will shorten the duration of analgesia. The patient should use the lowest effective dose of the drug.

If a second cartridge is used, proceed as follows:

1. Remove the button from the device and remove the used cartridge.

2. Insert the cartridge with the drug Umerox^® Inhal.

3. Return the button to its original position. Continue use as previously described, starting with Step 1 of the “How to use” section.

A maximum of 2 cartridges can be used with one Umerox^® Inhal device.

The maximum weekly dose is 15 ml.

It is not recommended to use the product for several days in a row.

After use, the medical device should be disposed of in accordance with local waste disposal requirements.

If you need additional information, please contact the YURiА-PHARM representative in your region.

You can also call 0800402022 or send your request to the email address info@uf.ua with your contact phone number and place of work so that a company representative will contact you directly.

Sources of information:

1. Keith M Porter, Anthony D Dayan, Sara Dickerson, Paul M Middleton, Published 18 October 2018 Volume 2018:10 Pages 149—164. The role of inhaled methoxyflurane in acute pain management, doi.org/10.2147/OAEM.S181222.

2. Дмитрієв Д. В., Назарчук О. А., Бабіна Ю. М., Метоксифлуран – інгаляційний анальгетик, що відкриває нові можливості у знеболенні, PainMedicine Journal, Том 8, No 1–2 • 2023. DOI: 10.31636/pmjua.v8i1-2.2.

3. Дубров Сергій Олександрович, Черняєв Степан Володимирович, Метоксифлуран: історичний огляд та аналіз безпеки використання як анальгетика при невідкладних та амбулаторних процедурах. Журнал “Pain, Anaesthesia & Intensive Care”, № 3, 2024.